NAD+ Complex

Neumina NAD+ Complex is positioned as a multi-ingredient healthy aging formula rather than a single-compound NAD product. It combines NAD+, trans-resveratrol, quercetin, fisetin, turmeric, black pepper extract, and high-dose biotin. The goal is to pair cellular energy with optimized antioxidant support and skin-hair-nail nutrition in one routine. Because botanical compounds like curcumin are rapidly metabolized by the liver, we include black pepper extract (piperine). Clinical research in humans has shown that this specific combination can increase the bioavailability of curcumin by up to 2,000%, ensuring the active compounds actually reach your circulation.¹⁻³

No. NAD+ is the coenzyme itself, while NMN and NR are precursors your body can convert into NAD+. This distinction matters because the most robust human data to date are still for precursors. For example, a landmark eight-week trial in healthy older adults showed that a combination of a precursor and a polyphenol (similar to the resveratrol in our formula) increased blood NAD+ levels by 40% to 90%, depending on the dose. This sustained increase highlights why we pair our complex with high-purity botanicals to support a comprehensive metabolic response. By contrast, evidence for direct oral NAD+ supplementation is more limited, so this formula is best positioned as a broader wellness supplement rather than a guaranteed "direct NAD booster."²⁻⁴

If you are pregnant, breastfeeding, taking prescription medications, or being monitored for thyroid, cardiac, or hormone-related lab tests, consult your healthcare professional before use. Extra caution is warranted if you take anticoagulants or drugs with high interaction potential, as ingredients such as turmeric, resveratrol, quercetin, and black pepper extract may affect absorption, metabolism, or bleeding risk. Additionally, the biotin content can complicate the interpretation of certain laboratory results.⁵⁻⁷

1. Peluso A, Zhang Y, Ji Y, et al. Age-dependent decline of NAD+-universal truth or confounded consensus?. Nutrients. 2021;14(1):9. doi:10.3390/nu14010009

2. Vinten KT, Trętowicz M, Coskun E, et al. NAD+ precursor supplementation in human ageing: clinical evidence and challenges. Nat Metab. 2025;7(10):1974-1990. doi:10.1038/s42255-025-01387-7

3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17. doi:10.1038/s41514-017-0016-9

4. Hodzic Kuerec A, Wang W, Yi L, et al. Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration. Mech Ageing Dev. 2024;218:111917. doi:10.1016/j.mad.2024.111917

5. Office of Dietary Supplements, National Institutes of Health. Biotin fact sheet for health professionals. Accessed April 22, 2026.

6. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-356. doi:10.1055/s-2006-957450

7. Calvo-Castro L, Schiborr C, David F, et al. The oral bioavailability of trans-resveratrol from a grapevine-shoot extract in healthy humans is significantly increased by micellar solubilization. Mol Nutr Food Res. 2018;62(9):e1701057. doi:10.1002/mnfr.201701057